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Jean L Rouleau Selected Research

sacubitril and valsartan sodium hydrate drug combination

1/2022Angiotensin-neprilysin inhibition and renal outcomes across the spectrum of ejection fraction in heart failure.
8/2021Development and external validation of prognostic models to predict sudden and pump-failure death in patients with HFrEF from PARADIGM-HF and ATMOSPHERE.
1/2021Effect of sacubitril/valsartan vs. enalapril on changes in heart failure therapies over time: the PARADIGM-HF trial.
1/2021Sacubitril-valsartan as a treatment for apparent resistant hypertension in patients with heart failure and preserved ejection fraction.
1/2021Clinical Characteristics and Outcomes of Patients With Heart Failure With Reduced Ejection Fraction and Chronic Obstructive Pulmonary Disease: Insights From PARADIGM-HF.
11/2020Serum uric acid, influence of sacubitril-valsartan, and cardiovascular outcomes in heart failure with preserved ejection fraction: PARAGON-HF.
1/2020Prognostic Models Derived in PARADIGM-HF and Validated in ATMOSPHERE and the Swedish Heart Failure Registry to Predict Mortality and Morbidity in Chronic Heart Failure.
10/2019Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction.
10/2019Prognostic Implications of Congestion on Physical Examination Among Contemporary Patients With Heart Failure and Reduced Ejection Fraction: PARADIGM-HF.
1/2019B-Type Natriuretic Peptide During Treatment With Sacubitril/Valsartan: The PARADIGM-HF Trial.
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Jean L Rouleau Research Topics

Disease

127Heart Failure
12/2022 - 05/2002
23Myocardial Infarction
01/2022 - 01/2002
17Left Ventricular Dysfunction
11/2018 - 06/2004
16Coronary Artery Disease (Coronary Atherosclerosis)
12/2022 - 11/2004
16Cardiomyopathies (Cardiomyopathy)
12/2022 - 12/2007
7Stroke (Strokes)
01/2022 - 04/2004
7Atrial Fibrillation
01/2020 - 05/2006
6Hypotension (Low Blood Pressure)
10/2019 - 01/2002
6Ventricular Remodeling
05/2015 - 05/2002
5Heart Diseases (Heart Disease)
01/2022 - 01/2017
5Cardiovascular Diseases (Cardiovascular Disease)
11/2018 - 04/2002
5Fibrosis (Cirrhosis)
12/2003 - 01/2002
4Chronic Renal Insufficiency
01/2022 - 12/2004
4Heart Arrest (Cardiac Arrest)
01/2021 - 06/2005
4Hyperkalemia
10/2019 - 09/2014
4Sudden Death
06/2017 - 10/2002
4Cicatrix (Scar)
12/2003 - 01/2002
3Type 2 Diabetes Mellitus (MODY)
01/2022 - 04/2003
3Angioedema
10/2019 - 10/2005
3Edema (Dropsy)
10/2019 - 01/2019
3Coronary Disease (Coronary Heart Disease)
10/2018 - 11/2004
3Acute Coronary Syndrome
05/2014 - 04/2004
3Hypertrophy
05/2002 - 01/2002
2Chronic Obstructive Pulmonary Disease (COPD)
12/2021 - 01/2021
2Diabetes Mellitus
01/2020 - 01/2016
2Inflammation (Inflammations)
01/2020 - 04/2006
2Dyspnea (Shortness of Breath)
10/2019 - 02/2009
2Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
01/2019 - 09/2002
2Cardiac Sudden Death (Sudden Cardiac Arrest)
03/2017 - 08/2015
2Insulin Resistance
01/2017 - 04/2003
2Ischemia
06/2015 - 01/2008
2Infarction (Infarctions)
10/2009 - 05/2002
2Angina Pectoris
02/2008 - 05/2004
2Unstable Angina
01/2008 - 04/2004
1Peripheral Vascular Diseases (Peripheral Vascular Disease)
01/2022
1Chronic Kidney Failure (Chronic Renal Failure)
01/2022
1Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
08/2021
1Bundle-Branch Block (Fascicular Block)
08/2021
1Neoplasms (Cancer)
08/2021
1Pneumonia (Pneumonitis)
01/2021

Drug/Important Bio-Agent (IBA)

35sacubitril and valsartan sodium hydrate drug combinationIBA
01/2022 - 07/2014
27Neprilysin (Neutral Endopeptidase)IBA
01/2022 - 09/2002
25Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
01/2021 - 05/2002
23EnalaprilFDA LinkGeneric
01/2022 - 09/2005
20Brain Natriuretic Peptide (Natrecor)FDA Link
01/2022 - 09/2004
19Angiotensin Receptors (Angiotensin II Receptor)IBA
12/2021 - 09/2014
13pro-brain natriuretic peptide (1-76)IBA
01/2022 - 03/2004
13Natriuretic PeptidesIBA
01/2022 - 09/2002
11Mineralocorticoid Receptor AntagonistsIBA
01/2022 - 01/2017
9DiureticsIBA
01/2022 - 02/2008
9paragonIBA
12/2021 - 01/2017
9Biomarkers (Surrogate Marker)IBA
01/2021 - 06/2003
8Valsartan (Vals)FDA Link
01/2022 - 01/2008
7CreatinineIBA
01/2022 - 10/2006
7aliskirenFDA Link
08/2021 - 05/2011
7Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
01/2017 - 11/2004
6Spironolactone (Aldactone)FDA LinkGeneric
01/2022 - 01/2018
6Carvedilol (Coreg)FDA LinkGeneric
09/2004 - 01/2002
5AngiotensinsIBA
01/2022 - 09/2014
5Angiotensin Receptor AntagonistsIBA
12/2021 - 07/2007
5Troponin T (Troponin T1)IBA
01/2019 - 12/2009
5Pharmaceutical PreparationsIBA
01/2019 - 05/2004
5CytokinesIBA
09/2002 - 01/2002
4Peptides (Polypeptides)IBA
01/2021 - 06/2003
3Trinitrotoluene (TNT)IBA
01/2019 - 03/2013
3Troponin IIBA
11/2018 - 01/2005
3Quinapril (Accupril)FDA LinkGeneric
06/2015 - 06/2002
3ReninIBA
02/2012 - 09/2005
3candesartanIBA
07/2006 - 09/2005
3Captopril (Capoten)FDA LinkGeneric
11/2004 - 05/2002
3Vasopeptidase InhibitorsIBA
12/2003 - 05/2002
3omapatrilatIBA
12/2003 - 05/2002
2PotassiumIBA
01/2021 - 01/2017
2Uric Acid (Urate)IBA
11/2020 - 01/2018
2Therapeutic UsesIBA
01/2018 - 06/2005
2EnzymesIBA
01/2017 - 01/2008
2Pravastatin (Pravachol)FDA LinkGeneric
05/2014 - 04/2004
2Atorvastatin (Lipitor)FDA Link
05/2014 - 04/2004
2Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
05/2014 - 04/2004
2trandolapril (Mavik)FDA LinkGeneric
07/2007 - 11/2004
2Neurotransmitter Agents (Neurotransmitter)IBA
09/2005 - 09/2002
2Atrial Natriuretic Factor (ANF)IBA
09/2005 - 06/2005
2flosequinanIBA
01/2005 - 11/2002
2Endothelins (Endothelin)IBA
10/2003 - 06/2003
2Endothelin Receptors (Endothelin Receptor)IBA
10/2003 - 06/2003
2Endothelin-1 (Endothelin 1)IBA
06/2003 - 09/2002
2BradykininIBA
04/2003 - 09/2002
2Vasodilator Agents (Vasodilators)IBA
11/2002 - 04/2002
2AntioxidantsIBA
05/2002 - 01/2002
2Probucol (Lorelco)FDA Link
05/2002 - 01/2002
1ChloridesIBA
08/2021
1Serum AlbuminIBA
08/2021
1Galectin 3 (LGALS3)IBA
01/2021
1Antihypertensive Agents (Antihypertensives)IBA
01/2021
1Collagen Type III (Type III Collagen)IBA
01/2021
1Calcium Channel Blockers (Blockers, Calcium Channel)IBA
01/2021

Therapy/Procedure

47Therapeutics
12/2022 - 09/2002
23Coronary Artery Bypass (Coronary Artery Bypass Surgery)
12/2022 - 12/2007
6Patient Readmission
01/2022 - 04/2004
2Drug Therapy (Chemotherapy)
05/2014 - 05/2004